Boosting Stem Cell Research: Durham Company, France-Based Biotech Strike Testing Partnership | WRAL TechWire

RESEARCH TRIANGLE PARK KaryoLogic, a Durham-based karyotyping services company, is collaborating with a French biotech company to test and analyze chromosomes in human stem cells.

  • WHAT IS THE KARYOTYPE?Karyotyping is a test for examining the chromosomes in a sample of cells. This test can help identify genetic problems as the cause of a disorder or disease. (Medlineplus.gov)

The partnership with Stem Genomics of Montpellier, France will allow KaryoLogic to offer a digital test that can identify more than 90 percent of the most common genomic abnormalities found in human pluripotent stem cells, according to KaryoLogic.

The future of stem cells as biological products is promising, said Elizabeth Gonzalez, founder and chief executive officer of KaryoLogic. KaryoLogic and our new partner Stem Genomics are poised to be hugely influential in this field.

The digital test, based on polymerase chain reaction (PCR) technology, will help stem cell researchers detect chromosomal defects that are beyond the resolution of a traditional testing method known as G-band karyotyping.

Stem Genomics recently established a US subsidiary in Durham, together with KaryoLogic. collaborate in the testing service.

The two companies will market their combined tests as a two-in-one solution called Duo iCS-Karyo. The service combines G-band karyotype analysis with high-resolution digital PCR, providing a rigorous detection solution for testing the genomic integrity of human pluripotent stem cells, according to KaryoLogic.

Researchers will also be able to order one of the tests as standalone services.

The karyotype is the analysis of the chromosomes, the threadlike structures in the cells that carry the DNA, the genetic information for the construction and maintenance of a living organism. The karyotype is used to help identify genetic defects that can cause disease and disorder.

Gonzalez, who is also the company’s senior cytogeneticist, founded KaryoLogic in 2008 after two decades of work in the clinical cytogenetics, university research and genetic toxicology industry. He holds a Bachelor of Science from Cornell University and a Master of Science from Rutgers University.

Elizabeth González, KaryoLogic. (Photo from KaryoLogic)

He began learning and working with human karyotype, the complete set of chromosomes in 1982, then mastered the more challenging mouse karyotype in 1992.

In addition to human and mouse karyotyping, KaryoLogic offers the service for pigs, cats, dogs, Chinese hamsters, rats, sheep and chickens, and is open to other species, according to customers’ needs.

Clients include university research laboratories, cancer research institutes, and companies and institutes involved in stem cell gene editing, cell therapy, and regenerative medicine. Most are domestic, but the company has also done business with clients from the UK, Israel, Switzerland, Austria and Hong Kong.

Test results are usually returned in one to two weeks. Couriers are available to collect cell samples from customers in the research triangle area, while customers far away can ship cells overnight.

KaryoLogic has four employees, but the staff will likely grow as the partnership with Stem Genomics brings in new business, Gonzalez said.

Stem Genomics is a 2018 spin-out of the Institute for Regenerative Medicine & Biotherapy in Montpellier, France. The company, which specializes in the design of innovative stem cell testing technologies, has more than 150 customers worldwide including academic institutions, biotech companies and central facilities. US customers include companies and laboratories such as Synthego and Harvard Stem Cell Institute.

(C) NC Biotechnology Center

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